反应详情

A suspension of 5-(N-acetylamino)-2-chloro-4-fluorophenylthioacetic acid (89.8 g) in a 10% aqueous hydrochloric acid solution was refluxed for 2 hours under heating. After being allowed to cool, an aqueous solution of sodium hydroxide was added to make the suspension at pH 4. After ice-cooling, the precipitated crystals were collected by filteration, washed with ice-water and dried to give 55.0 g of 5-amino-2-chloro-4-fluorophenylthioacetic acid.

1. temperaturewas refluxed for 2 hours
2. temperatureunder heating
3. temperatureto cool
4. temperatureAfter ice-cooling
5. customthe precipitated crystals were collected by filteration
6. washwashed with ice-water
7. customdried