Methanol → HCID 66633824, compound

HRID 1788795Notes

Reaction equation

HRID 1788795 reaction equation
[N+:1]([CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:6](=[O:7])[O:5]1)([O-])=O.[CH3:14]O>>[CH:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:14][N:1]=1.[C:6]1([C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][O:5]1)=[O:7]

Participants

3

Reactant 2

HCID 887MethanolHCID 12217806HCID 12217806, compound

Product 1

HCID 66633824HCID 66633824, compound

Procedure

wherein R4 to R7 are as defined above, in methanol in an amount of 1.5 to 10 times by volume of nitrophthalide and a reaction temperature of 50° to 80° C. for a reaction period of 8 to 36 hours to produce a phthalide isoquinoline represented by the general formula (III): ##STR11##

Workup

  1. customa reaction temperature of 50° to 80° C. for a reaction period of 8 to 36 hours

Sources & evidence

ORD record
ord-39e3a70ecded4f8ea6d40804995deae2
Source dataset
uspto-grants-1987_08
Patent number
US04684732

Reaction notes

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