Thionyl Chloride → Benzoyl chloride, 2,5-bis(2,2,2-trifluoroethoxy)-

HRID 1788810ノート

反応式

HRID 1788810 の反応式
[F:1][C:2]([F:21])([F:20])[CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:10][C:6]=1[C:7](O)=[O:8].S(Cl)([Cl:24])=O>C1C=CC=CC=1>[F:1][C:2]([F:21])([F:20])[CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:10][C:6]=1[C:7]([Cl:24])=[O:8]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 27360782,5-bis(2,2,2-trifluoroethoxy)benzoic Acid

生成物 1

HCID 11427683Benzoyl chloride, 2,5-bis(2,2,2-trifluoroethoxy)-

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a solution of 0.688 mole (219 g.) of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid in 657 ml. of benzene is added 1.376M. (100.4 ml.) of thionyl chloride slowly over 1 hour while heating to about 60° C. The mixture is then heated at reflux for about 8 hours, then evaporated to provide the desired product, 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid chloride as a residue. The structure is verified by means of infrared spectral analysis.

後処理

  1. temperatureThe mixture is then heated
  2. temperatureat reflux for about 8 hours
  3. customevaporated

出典と根拠

ORDレコード
ord-91f05881152f4417803aa3e3b341a28e
出典データセット
uspto-grants-1987_08
特許番号
US04684733

反応ノート

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