Triphenylphosphine → HCID 13578044, compound

HRID 1788837Notes

Reaction equation

HRID 1788837 reaction equation
C(S([CH:6]1[N:9]([CH:10]([C:24]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[S:25])[C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)=[O:12])[C:8](=[O:33])[CH2:7]1)=O)C=C.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCOCC1>[O:33]=[C:8]1[N:9]2[CH:6]([S:25][C:24]([O:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[C:10]2[C:11]([O:13][CH2:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)=[O:12])[CH2:7]1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 13578043HCID 13578043, compound

Product 1

HCID 13578044HCID 13578044, compoundYield 18%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A stirred solution of 97 mg of 4-nitrobenzyl 2-(4-allylsulphinylazetidin-2-on-1-yl)-3-phenoxy-3-thioxopropionate and 52 mg of triphenylphosphine in 2 ml of dry dioxan was heated under an argon atmosphere under reflux for 15 minutes. The mixture was then evaporated in vacuo to dryness; chromatography over silica gel afforded 14 mg of the title compound (18% theoretical yield).

Workup

  1. temperatureunder reflux for 15 minutes
  2. customThe mixture was then evaporated in vacuo to dryness

Sources & evidence

ORD record
ord-ff18f171073b41e1bae56734e71a1c01
Source dataset
uspto-grants-1987_08
Patent number
US04684640

Reaction notes

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