反应详情

温度

150 °C

2-Bromo-3-phenyl-6-(3-phenylpropoxy)indene-1-one (1.0 g, 2.3 mmol) was dissolved in N,N-dimethylformamide (10 ml). Copper (I) cyanide (617 mg, 6.9 mmol) was added thereto and the mixture was stirred for 3 hours at 150° C. The mixture was cooled, and saturated ammonium chloride was added thereto. The organic layer was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3) to obtain the title compound (700 mg, yield 80%) as a red solid.

1. temperatureThe mixture was cooled
2. extractionThe organic layer was extracted with ethyl acetate
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated
5. customthe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:3)