反应详情

A mixture of 1.74 g of 2,3-epoxy-2,3-dihydro-1,4-naphthoquinone and 2.30 g of N-[3-(trifluoromethyl)phenyl]piperazine in 100 ml of absolute ethanol was stirred for 20 hours, then evaporated. The residue was dissolved in dichloromethane, filtered through hydrous magnesium silicate and then chromatographed on silica gel, eluting with hexane:ethyl acetate (4:1), giving 1.2 g of the desired product, mp 167°-169° C.

1. customevaporated
2. dissolutionThe residue was dissolved in dichloromethane
3. filtrationfiltered through hydrous magnesium silicate
4. customchromatographed on silica gel
5. washeluting with hexane:ethyl acetate (4:1)