HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 178516902, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-(Trifluoromethyl)phenyl)piperazine | HCID 4296 | — |
| Reactant | 2,3-Epoxy-2,3-dihydro-1,4-naphthoquinone | HCID 85844 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178516902 | HCID 178516902 | 29.9% |
Reaction Steps
A mixture of 1.74 g of 2,3-epoxy-2,3-dihydro-1,4-naphthoquinone and 2.30 g of N-[3-(trifluoromethyl)phenyl]piperazine in 100 ml of absolute ethanol was stirred for 20 hours, then evaporated. The residue was dissolved in dichloromethane, filtered through hydrous magnesium silicate and then chromatographed on silica gel, eluting with hexane:ethyl acetate (4:1), giving 1.2 g of the desired product, mp 167°-169° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04686220 |
| Source dataset | uspto-grants-1987_08 |
| ORD ID | ord-ce5069d4005549b6a217e8c95207166c |
| Source note | uspto-grants-1987_08 |