Methyl iodide → HCID 13821868, compound

HRID 1788924Notes

Reaction equation

HRID 1788924 reaction equation
[CH3:1][I:2].[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]1=[N:14][C:15]([CH3:21])=[C:16]([CH2:17][N:18]([CH3:20])[CH3:19])[N:9]1[CH:8]=[CH:7]2>C(O)C>[I-:2].[Cl:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]1=[N:14][C:15]([CH3:21])=[C:16]([CH2:17][N+:18]([CH3:1])([CH3:20])[CH3:19])[N:9]1[CH:8]=[CH:7]2

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 13821832HCID 13821832, compound

Product 1

HCID 13821868HCID 13821868, compoundYield 84.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyliodide (1.7 g) was added dropwise to a solution of 8-chloro-3-dimethylaminomethyl-2-methylimidazo[2,1-a]isoquinoline (2.8 g) in ethanol (34 ml) at room temperature and the mixture was stirred for 14 hours. The resulting precipitate was collected by filtration, washed with ethanol and dried in a desiccator to give 8-chloro-2-methyl-3-trimethylammoniomethylimidazo[2,1-a]isoquinoline iodide (3.58 g).

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with ethanol
  3. customdried in a desiccator

Sources & evidence

ORD record
ord-93256b0b1b2d4e259b6a55c562dc49d1
Source dataset
uspto-grants-1987_08
Patent number
US04686227

Reaction notes

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