Hydrochloric Acid → Piperazin-1-ol dihydrochloride
Reaction equation
[OH:1][N:2]1[CH2:7][CH2:6][N:5](C=O)[CH2:4][CH2:3]1.[ClH:10]>>[ClH:10].[ClH:10].[OH:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1Participants
3
Procedure
That is, 1-formylpiperazine (IV) is reacted with ethyl acrylate to give a compound (V), and the resulting compound is treated with an oxidizing agent (e.g. hydrogen peroxide) preferably in the presence of a catalyst (e.g. sodium tungstate) to give 4-hydroxy-1-formylpiperazine (VI). The compound (VI) is hydrolyzed with hydrochloric acid to give 1-hydroxypiperazine dihydrochloride (III). ##STR7## wherein R and X are as defined above.
Sources & evidence
- ORD record
- ord-46717d15a606428ab609af8026fb6e88
- Source dataset
- uspto-grants-1987_08
- Patent number
- US04686221
Reaction notes
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