反应详情

A mixture of 4.7 g of 2-acetylamino-5-chloro-2',4',6'-trimethoxybenzophenone, 50 ml of 6N hydrochloric acid and 50 ml of ethanol was refluxed for 1 hour while heating. After the solvent was distilled off, the residue was basefied with an aqueous solution of sodium hydrogen carbonate and then extracted with ethyl acetate. After the extract was washed with water and dried, the solvent was removed, and the residue was subjected to silica gel column chromatography to yield 3.75 g of a crystal.

1. temperaturewas refluxed for 1 hour
2. temperaturewhile heating
3. distillationAfter the solvent was distilled off
4. extractionextracted with ethyl acetate
5. washAfter the extract was washed with water
6. customdried
7. customthe solvent was removed