2-Fluoro-6-(trifluoromethyl)benzaldehyde → 3-Methyl 5-(1-methylethyl) 2-(fluoromethyl)-4-(2-fluoro-6-(trifluoromethyl)phenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Participants

Reaction Steps

2-Fluoro-6-(trifluoromethyl)benzaldehyde (1.51 g, 7.8 mmoles), methyl 4-fluoro-3-oxobutanoate (1.06 g, 7.8 mmoles) and 1-methylethyl 3-amino-2-butenoate (1.13 g, 7.8 mmoles) were heated at 90° under nitrogen with stirring for 2 hours. The cooled reaction mixture was chromatographed twice; first eluting with toluene/ethyl acetate mixtures and then with ethyl acetate/petroleum ether (60°-80°) mixtures. The title compound (0.1 g) was obtained on evaporation of the pure fractions mp 82°-4°.

Provenance & Evidence