HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydro-4H-pyran-4-ol → Tetrahydro-4H-pyran-4-yl 3-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydro-4H-pyran-4-ol | HCID 74956 | — |
| Reactant | 5-Acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 2763470 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Tetrahydro-4H-pyran-4-yl 3-oxobutanoate | HCID 20189394 | — |
Reaction Steps
A solution of tetrahydro-4H-pyran-4-ol (1.6 ml, 16.8 mmoles) and 5-acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione (3.0 g, 16.1 mmoles) in dry benzene (50 ml) was heated under reflux for 4 hours. The solvent was removed in vacuo and the residue distilled at 146°-151°/14 mm Hg to afford the title product as a colourless oil, 2.84 g. Nmr (CDCl3)δ5.1 (m,H), 3.5 (s,3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04686217 |
| Source dataset | uspto-grants-1987_08 |
| ORD ID | ord-cb09f0193b7f4887922c4b589c6703b0 |
| Source note | uspto-grants-1987_08 |