反应详情

A solution of tetrahydro-4H-pyran-4-ol (1.6 ml, 16.8 mmoles) and 5-acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione (3.0 g, 16.1 mmoles) in dry benzene (50 ml) was heated under reflux for 4 hours. The solvent was removed in vacuo and the residue distilled at 146°-151°/14 mm Hg to afford the title product as a colourless oil, 2.84 g. Nmr (CDCl3)δ5.1 (m,H), 3.5 (s,3H).

1. temperatureunder reflux for 4 hours
2. customThe solvent was removed in vacuo
3. distillationthe residue distilled at 146°-151°/14 mm Hg