HCID 13912878, compound → HCID 13912880, compound

HRID 1789079Notes

Reaction equation

HRID 1789079 reaction equation
[NH2:1][C:2]1[C:3]([N+:13]([O-])=O)=[CH:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([NH2:9])=[O:8]>CO.[C].[Pd]>[NH2:13][C:3]1[C:2]([NH2:1])=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[C:5]([O:11][CH3:12])[CH:4]=1

Participants

4

Reactant 1

HCID 13912878HCID 13912878, compound

Product 1

HCID 13912880HCID 13912880, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A suspension of 3.04 g of 5-amino-2-methoxy-4-nitrobenzamide and 110 mg of 10 % palladium carbon in 300 ml of methanol was stirred at 60° C. under a hydrogen atmosphere. After absorption of hydrogen was completed, the catalyst was removed by filtration, and the filtrate was concentrated to give the title compound, m.p. 181°-183° C., yield of 2.18 g.

Workup

  1. customAfter absorption of hydrogen
  2. customthe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-491a4f8f742343318b3697e3cf01bfb4
Source dataset
uspto-grants-1987_08
Patent number
US04686292

Reaction notes

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