Benzyl piperazine-1-carboxylate → HCID 131715233, compound

HRID 1789185Notes

Reaction equation

[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[CH:4]=[CH:3][NH:2]1.[C:11](N1CCNCC1)([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12]>N1C=CC=CC=1>[C:11]([C:3]1[NH:2][O:1][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[CH:4]=1)([O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:12]

Participants

Conditions

Temperature: 70 °C

Procedure

To a solution of 2.1 g of the benzoxazine (E) (R8 =CH3, R9 =C2H5, R10 =C6H5, X=F), in 30 ml pyridine is added 8 g of N-carbobenzoxypiperazine. The mixture is heated at 70° C. for 18 hours. The solvent is removed by evaporation under reduced pressure. The residue is washed with ether, water and ether. It is dried, yielding 2.45 g of the carbobenzoxy-benzoxazine (F) (R8 =CH3, R9 =C2H5, R10 =C6H5, Z=carbobenzoxy-piperazin-1-yl).

Workup

customThe solvent is removed by evaporation under reduced pressure
washThe residue is washed with ether, water and ether
customIt is dried

Sources & evidence

ORD record: ord-8873734d8647430fb21a9471e9a9557b
Source dataset: uspto-grants-1987_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04687770

Reaction notes

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