Benzyl piperazine-1-carboxylate → HCID 131715233, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2.1 g of the benzoxazine (E) (R8 =CH3, R9 =C2H5, R10 =C6H5, X=F), in 30 ml pyridine is added 8 g of N-carbobenzoxypiperazine. The mixture is heated at 70° C. for 18 hours. The solvent is removed by evaporation under reduced pressure. The residue is washed with ether, water and ether. It is dried, yielding 2.45 g of the carbobenzoxy-benzoxazine (F) (R8 =CH3, R9 =C2H5, R10 =C6H5, Z=carbobenzoxy-piperazin-1-yl).

Provenance & Evidence