反应详情

3-Oxo-3-m-tolylpropionate ethyl ester (1 g, 4.84 mmol) was dissolved in benzene, and benzaldehyde (0.51 g, 4.84 mmol), acetic acid (0.15 g, 2.49 mmol) and piperidine (0.06 g, 0.8 mmol) were added thereto. The mixture was refluxed for 4 hours. After the reaction was completed, the organic layer extracted with ethyl acetate/saturated sodium chloride/sodium bicarbonate was dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography to obtain 2-(3-methylbenzoyl)-3-phenylacrylate ethyl ester (1 g, yield 70%).

1. temperatureThe mixture was refluxed for 4 hours
2. extractionthe organic layer extracted with ethyl acetate/saturated sodium chloride/sodium bicarbonate
3. dry with materialwas dried over anhydrous magnesium sulfate
4. concentrationconcentrated
5. customthe resulting residue was purified by column chromatography