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HRID1789229

反应详情

EQUATION

反应方程式

HRID 1789229 的结构方程式

REACTANTS

反应物

3
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：O=C1CCC(=O)N1O
HCID80170

2,5-Pyrrolidinedione, 1-hydroxy-

C4H5NO3

结构：O=C(O)[C@@H]1CCCN1C(=O)OCc1ccccc1
HCID101987

Carbobenzoxyproline

C13H15NO4

PRODUCTS

生成物

1
结构：O=C(ON1C(=O)CCC1=O)[C@@H]1CCCN1C(=O)OCc1ccccc1
HCID853482

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

Z-Pro (7.5 gm, 0.03 mole) and N-Hydroxysuccinimide (3.45 gm, 0.03 mole) were dissolved in cold dioxane and dicyclohexylcarbodiimide (DCC) (6.18 gm, 0.03 mole) was added with rapid stirring. The mixture was stirred overnight at room temperature and the next day the solid dicyclohexylurea (DCU) was filtered off. The solvent was removed and the oil was recrystallized from isopropyl alcohol. Crystals of Z-Pro-OSu formed with scratching. Yield 8.4 gm. Melting point 86.5°-87.5° C.

WORKUP

后处理

  1. filtrationthe next day the solid dicyclohexylurea (DCU) was filtered off
  2. customThe solvent was removed
  3. customthe oil was recrystallized from isopropyl alcohol