反应详情

2-Ethylcyclohexanol (1.6 moles, 204 g, 226 mL) was stirred in 3.21 of acetone at 0° C. and treated with 8N Jones reagent (prepared from 106.8 g of CrO3 suspended in 92 mL of concentrated sulfuric acid and diluted to 400 mL with water) until the orange color persisted (~430 mL). Isopropanol was then added to turn the solution green again after which it was poured into 2 l of ether. The product was washed with 6×500 ml of brine, dired over MgSO4 and stripped of solvent. Short path distillation (b.p. 80°-85° C. at 25 mm) afforded 184 g (1.46 moles, 91%) of 2-ethylcyclohexanone as a colorless oil.

1. washThe product was washed with 6×500 ml of brine
2. distillationShort path distillation (b.p. 80°-85° C. at 25 mm)