2,5-Dimethoxytetrahydrofuran → HCID 20188387, compound

HRID 1789345Notes

Reaction equation

HRID 1789345 reaction equation
CO[CH:3]1[CH2:7][CH2:6][CH:5](OC)O1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([O:19][CH3:20])=[O:18])[N:12]=1>C(O)(=O)C>[N:10]1([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([O:19][CH3:20])=[O:18])[N:12]=2)[CH:3]=[CH:7][CH:6]=[CH:5]1

Participants

4

Reactant 2

HCID 790982,5-DimethoxytetrahydrofuranHCID 13809143Methyl 6-aminopyridine-2-carboxylate

Product 1

HCID 20188387HCID 20188387, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

6.3 ml of 2,5-dimethoxy-tetrahydrofuran were added with stirring at room temperature to a solution of 7 g of the product of Step C in 17.5 ml of acetic acid and was refluxed for one hour. Acetic acid was evaporated under reduced pressure and the oil residue was chromatographed over silica gel. Elution with methylene chloride yielded 3.7 g of 2-(pyrrol-1-yl)-6-methoxy carbonyl-pyridine melting at 61° C.

Workup

  1. temperaturewas refluxed for one hour
  2. customAcetic acid was evaporated under reduced pressure
  3. customthe oil residue was chromatographed over silica gel
  4. washElution with methylene chloride

Sources & evidence

ORD record
ord-7ab193707983430c94d04bf84c07320d
Source dataset
uspto-grants-1987_08
Patent number
US04689342

Reaction notes

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