2,5-Dimethoxytetrahydrofuran → HCID 20188387, compound

Participants

Reaction Steps

6.3 ml of 2,5-dimethoxy-tetrahydrofuran were added with stirring at room temperature to a solution of 7 g of the product of Step C in 17.5 ml of acetic acid and was refluxed for one hour. Acetic acid was evaporated under reduced pressure and the oil residue was chromatographed over silica gel. Elution with methylene chloride yielded 3.7 g of 2-(pyrrol-1-yl)-6-methoxy carbonyl-pyridine melting at 61° C.

Provenance & Evidence