Thionyl Chloride → HCID 53651586, compound

HRID 1789390Notes

Reaction equation

HRID 1789390 reaction equation
[CH3:1][C@@H:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C@@H:3]1[C:11]([OH:13])=O.S(Cl)([Cl:16])=O>>[CH3:1][C@@H:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C@@H:3]1[C:11]([Cl:16])=[O:13]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 18609505HCID 18609505, compound

Product 1

HCID 53651586HCID 53651586, compound

Procedure

cis-2,3-Dihydro-1-methyl-1H-indene-2-carboxylic acid (52.6 g) is converted to its acid chloride by treatment with thionyl chloride (130 ml). Excess thionyl chloride is distilled off and the acid chloride is distilled, b.p. 86°-89° C./0.45 mmHg. The yield is 47.9 g, 83%.

Workup

  1. distillationExcess thionyl chloride is distilled off
  2. distillationthe acid chloride is distilled

Sources & evidence

ORD record
ord-5a05f21af04347eba8fca34c13fc77a3
Source dataset
uspto-grants-1987_08
Patent number
US04689339

Reaction notes

Loading…