Propylamine → HCID 178457550, compound

HRID 1789410Notes

Reaction equation

HRID 1789410 reaction equation
[C:1]([N:3]=[C:4](SC)[NH:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1)#[N:2].[CH2:18]([NH2:21])[CH2:19][CH3:20]>C(#N)C>[C:1]([N:3]=[C:4]([NH:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH2:9][CH2:8][CH2:7]1)[NH:21][CH2:18][CH2:19][CH3:20])#[N:2]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 178503884HCID 178503884, compound

Product 1

HCID 178457550HCID 178457550, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 12.3 g of N'-cyano-N-(1,2,3,4-tetrahydro-1-napthyl)-S-methylisothiourea and 16 ml of n-propylamine in 100 ml of acetonitrile was heated at reflux with stirring for 20 hours. The reaction mixture was then allowed to stand in a refrigerator to give 8.63 g of N"-cyano-N-n-propyl-N'-(1,2,3,4-tetrahydro-1-naphthyl)guanidine as a white, crystalline solid, mp 130.5°-131.5° C. A further quantity of the product was obtained by the concentration and subsequent cooling of the mother liquor.

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-304c38d018044bb286d8a97c383e9f1c
Source dataset
uspto-grants-1987_08
Patent number
US04689348

Reaction notes

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