反应详情

The procedure followed is the same as that described in Example 7 substituting 5-chloropentan-3-ol {1-chloro-3-pentanol} (50 g, 0.41 moles), tert-butyldimethylsilyl chloride (71g, 0.47 moles), imidazole (32.6 g, 0.48 moles), and dimethylformamide (150 ml). The crude product is fractionally distilled under vacuum leaving a clear, colorless oil (78 g, 0.33 moles), BP 48° C./0.1 mm.

1. distillationThe crude product is fractionally distilled under vacuum