Ethylene carbonate → 4-(2-Hydroxyethoxy)-2-amino-1,3-benzoxazol

HRID 1789674Notes

Reaction equation

[OH:1][C:2]1[C:7]2[N:8]=[C:9]([NH2:11])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.C1(=O)O[CH2:15][CH2:14][O:13]1>>[OH:13][CH2:14][CH2:15][O:1][C:2]1[C:7]2[N:8]=[C:9]([NH2:11])[O:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7303Ethylene carbonate

HCID 218650524-Hydroxy-2-aminobenzoxazol

Product 1

HCID 220364604-(2-Hydroxyethoxy)-2-amino-1,3-benzoxazolYield 46%

Procedure

The title compound was prepared according to the procedure of Example 91, Step 1, starting from 4-hydroxy-2-amino-1,3-benzoxazol*(0.97 g, 6.5 mmol) and ethylene carbonate (0.63 g, 7.1 mmol). Solid; yield 46%; mp 124-126° C. Anal. (C9H10N2O3) C, H, N.

Sources & evidence

ORD record: ord-c401697294ae4fec9e6ff7729b9cf9ee
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07071180B2

Reaction notes

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