Hexahydro-1,4-diazepine → HCID 22036408, compound

HRID 1789681Notes

Reaction equation

HRID 1789681 reaction equation
Cl[C:2]1[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[N:6][CH:5]=[CH:4][N:3]=1.[NH:19]1[CH2:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[N:19]1([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:25][CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 68163Hexahydro-1,4-diazepineHCID 22036540HCID 22036540, compound

Product 1

HCID 22036408HCID 22036408, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(4-chlorophenoxy)ethoxy]pyrazine*(150 mg, 0.53 mmol) and homopiperazine (287 mg, 2.87 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 128 mg (69%) of the title product. HRMS m/z calcd for C17H21CIN4O2(M)+348.1353, found 348.1353. Anal. (C17H21CIN4O2) C, H, N.

Workup

  1. extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record
ord-c0f7b8e1a444474683b7d98b073af725
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

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