Hexahydro-1,4-diazepine → HCID 22036408, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(4-chlorophenoxy)ethoxy]pyrazine*(150 mg, 0.53 mmol) and homopiperazine (287 mg, 2.87 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 128 mg (69%) of the title product. HRMS m/z calcd for C17H21CIN4O2(M)+348.1353, found 348.1353. Anal. (C17H21CIN4O2) C, H, N.

Provenance & Evidence