2-Methylpiperazine → HCID 22036328, compound

HRID 1789684Notes

Reaction equation

Cl[C:2]1[C:7]([O:8][CH:9]([CH3:20])[CH2:10][O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[O:18][CH3:19])=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:21][CH:22]1[CH2:27][NH:26][CH2:25][CH2:24][NH:23]1>>[CH3:21][CH:22]1[NH:23][CH2:24][CH2:25][N:26]([C:2]2[C:7]([O:8][CH:9]([CH3:20])[CH2:10][O:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[O:18][CH3:19])=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:27]1

Participants

Reactant 2

HCID 660572-Methylpiperazine

HCID 22036298HCID 22036298, compound

Product 1

HCID 22036328HCID 22036328, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-[2-(2-methoxyphenoxy)-1-methylethoxy]pyrazine* (150 mg, 0.51 mmol) and 2-methylpiperazine (260 mg, 2.6 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 118 mg (65%) of the title product. HRMS m/z calcd for C19H26N4O3M)+358.2005, found 358.2018. Anal. (C19H26N4O3) C, H, N.

Workup

extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record: ord-f5791e102c0343dfa8efa4580994199c
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07071180B2

Reaction notes

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