2-Methylpiperazine → HCID 22036456, compound

HRID 1789685Notes

Reaction equation

Cl[C:2]1[C:7]([O:8][CH2:9][CH:10]2[O:15][C:14]3[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=3[O:12][CH2:11]2)=[N:6][CH:5]=[CH:4][N:3]=1.[CH3:20][CH:21]1[CH2:26][NH:25][CH2:24][CH2:23][NH:22]1>>[CH3:20][CH:21]1[NH:22][CH2:23][CH2:24][N:25]([C:2]2[C:7]([O:8][CH2:9][CH:10]3[O:15][C:14]4[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=4[O:12][CH2:11]3)=[N:6][CH:5]=[CH:4][N:3]=2)[CH2:26]1

Participants

Reactant 2

HCID 660572-Methylpiperazine

HCID 22036545HCID 22036545, compound

Product 1

HCID 22036456HCID 22036456, compound

Procedure

The title compound was prepared according to the procedure described in Example 4, Step 2, starting from 2-chloro-3-(2,3-dihydro-1,4-benzodioxin-2-ylmethoxy)pyrazine* (150 mg, 0.54 mmol) and 2-methylpiperazine (293 mg, 2.92 mmol) with the exception that a final extraction step between EtOAc and 5% aqueous NaOH was carried out. This gave 118 mg (64%) of the title product. HRMS m/z calcd for C18H22N4O3(M)+342.1692, found 342.1678. Anal. (C18H22N4O3) H, N; C: calcd, 63.14; found, 62.30.

Workup

extractionextraction step between EtOAc and 5% aqueous NaOH

Sources & evidence

ORD record: ord-16f323ae09594cbd9729c4735b9836cc
Source dataset: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07071180B2

Reaction notes

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