反应详情

A mixture of 2,3-dichloropyrazine (6.64 g, 44.6 mmol) and N-methyl-N-(2-phenoxyethyl)amine* (4.5 g, 29.8 mmol) in DMF (5 mL) was placed in a sealed Pyrex tube and heated in a microwave oven (Labwell MW10) for 1×2 min followed by 2×1 min at 75 W. The mixture was concentrated and the resulting oil was purified by column chromatography on silica using hexane/EtOAc (95:5 followed by 93:7) to give 5.56 g (71%) of the title product as a colorless oil. HRMS m/z calcd for C13H14CIN3O (M)+263.0825, found 263.0824.

1. customwas placed in a sealed Pyrex tube
2. temperatureheated in a microwave oven (Labwell MW10) for 1×2 min
3. customfollowed by 2×1 min at 75 W
4. concentrationThe mixture was concentrated
5. customthe resulting oil was purified by column chromatography on silica