Piperazine → HCID 22036265, compound

HRID 1789729Notes

Reaction equation

HRID 1789729 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][C:17]=1[F:18])[N:14]=[C:13](Cl)[C:12]([Cl:20])=[N:11]2>CCO>[Cl:20][C:12]1[C:13]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:14][C:15]2[C:10](=[CH:9][C:8]([F:7])=[C:17]([F:18])[CH:16]=2)[N:11]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 106812302,3-DICHLORO-6,7-DIFLUOROQUINOXALINE

Product 1

HCID 22036265HCID 22036265, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

Piperazine (0.86 g, 10 mmol) was added to a stirred suspension of 6,7-difluoro-2,3-dichloroquinoxaline*(1.18 g, 5 mmol) in EtOH (50 mL) at room temperature. The mixture was heated at 75° C. for 17 h, allowed to cool and filtered to give the product as a pale yellow solid: yield 0.40 g (28%); mp 294-297° C. (dec). MS m/z 285/287 (M+H)+.

Workup

  1. temperatureto cool
  2. filtrationfiltered

Sources & evidence

ORD record
ord-da890de3566e4b029fd14d35890a3490
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

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