Piperazine → HCID 22036309, compound

HRID 1789731Notes

Reaction equation

HRID 1789731 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[C:9]([Cl:17])=[N:10][C:11]2[C:12](=[CH:14][S:15][CH:16]=2)[N:13]=1>CCO>[Cl:17][C:9]1[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:13][C:12]2[C:11](=[CH:16][S:15][CH:14]=2)[N:10]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 15619274HCID 15619274, compound

Product 1

HCID 22036309HCID 22036309, compoundYield 29.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Piperazine (92 mg, 1.07 mmol) was added to a stirred suspension of 2,3-dichlorothieno[3,4-b]pyrazine (110 mg, 0.54 mmol) in EtOH (5 mL) at room temperature. The mixture was stirred at reflux for 16 h and filtered. The solid was purified by chromatography on silica gel (gradient: PhMe to PhMe/MeOH/Et3N, 8:1:1) to give 40 mg (29%) of the product as an orange solid. The material was used without further purification in the next step.

Workup

  1. temperatureat reflux for 16 h
  2. filtrationfiltered
  3. customThe solid was purified by chromatography on silica gel (gradient: PhMe to PhMe/MeOH/Et3N, 8:1:1)

Sources & evidence

ORD record
ord-bf174f0c7f1e4e9caee1592ec6ddfcab
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

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