HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2,3-Dihydro-1,4-benzodioxin-2-ylmethyl 3-(4-methyl-1 piperazinyl)-2-pyrazinyl ether, Dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Benzodioxane-2-methanol | HCID 19314 | — |
| Reactant | 2-Chloro-3-(4-methylpiperazin-1-YL)pyrazine | HCID 22036352 | — |
| Product | 2,3-Dihydro-1,4-benzodioxin-2-ylmethyl 3-(4-methyl-1 piperazinyl)-2-pyrazinyl ether, Dihydrochloride | HCID 131723550 | 87% |
Reaction Steps
The title compound was prepared according to the procedure described in Example 90, Step 2, starting from 1-(3-chloro-2-pyrazinyl)-4-methylpiperazine (described in Example 169, Step 1) and 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine. Yield 87%; mp 160-167° C. Anal. (C18H22N4O3.2 HCl) H, N; C: calcd, 52.06; found, 52.6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071180B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-6518bc6102d44ed2a4b1deaa03cf31ac |
| Source note | uspto-grants-2006_07 |