Hydrochloric Acid → 2,3-Dihydro-1,4-benzodioxin-2-ylmethyl 3-(4-methyl-1 piperazinyl)-2-pyrazinyl ether, Dihydrochloride

HRID 1789736Notes

Reaction equation

HRID 1789736 reaction equation
[Cl:1][C:2]1[C:3]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][N:7]=1.[OH:15][CH2:16][CH:17]1[O:22][C:21]2[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=2[O:19][CH2:18]1.[ClH:27]>>[ClH:1].[ClH:27].[CH3:14][N:11]1[CH2:12][CH2:13][N:8]([C:3]2[C:2]([O:15][CH2:16][CH:17]3[O:22][C:21]4[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=4[O:19][CH2:18]3)=[N:7][CH:6]=[CH:5][N:4]=2)[CH2:9][CH2:10]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 193141,4-Benzodioxane-2-methanolHCID 220363522-Chloro-3-(4-methylpiperazin-1-YL)pyrazine

Product 1

HCID 1317235502,3-Dihydro-1,4-benzodioxin-2-ylmethyl 3-(4-methyl-1 piperazinyl)-2-pyrazinyl ether, DihydrochlorideYield 87%

Procedure

The title compound was prepared according to the procedure described in Example 90, Step 2, starting from 1-(3-chloro-2-pyrazinyl)-4-methylpiperazine (described in Example 169, Step 1) and 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine. Yield 87%; mp 160-167° C. Anal. (C18H22N4O3.2 HCl) H, N; C: calcd, 52.06; found, 52.6.

Sources & evidence

ORD record
ord-6518bc6102d44ed2a4b1deaa03cf31ac
Source dataset
uspto-grants-2006_07
Patent number
US07071180B2

Reaction notes

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