HCID 131725826, compound → HCID 9881344, compound

HRID 1789787Notes

Reaction equation

HRID 1789787 reaction equation
[OH:1][C:2]([C:4](F)(F)F)=O.[SH:8][CH2:9][CH:10]([CH2:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[C:11]([OH:13])=[O:12]>C(OC(=O)C)(=O)C>[C:2]([N:18]1[CH2:19][CH2:20][CH:15]([CH2:14][CH:10]([CH2:9][SH:8])[C:11]([OH:13])=[O:12])[CH2:16][CH2:17]1)(=[O:1])[CH3:4]

Participants

3

Reactant 1

HCID 131725826HCID 131725826, compound

Product 1

HCID 9881344HCID 9881344, compoundYield 80.2%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of 2-Mercaptomethyl-3-piperidin-4-yl-propionic acid TFA salt (0.1 g, 0.32 mmol) in acetic anhydride (2 mL) was stirred over night under argon and then concentrated under reduced pressure. Purification by HPLC (10→50% acetonitrile, 0.1% TFA in water) gave the title compound (63 mg, 80%).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customPurification by HPLC (10→50% acetonitrile, 0.1% TFA in water)

Sources & evidence

ORD record
ord-65be9be147ec4d6cba76109aff30097f
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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