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HRID1789823

反应详情

EQUATION

反应方程式

HRID 1789823 的结构方程式

REACTANTS

反应物

1
反应SMILES：CCOC(=O)C(C)(CSC(C)=O)Cc1cnc(N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)c(C)c1
HCID54260523

未命名化合物

PRODUCTS

产物

1
反应SMILES：CCOC(=O)C(C)(CSC(C)=O)Cc1cnc(N)c(C)c1
HCID57201257

未命名化合物

收率 84%

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：O=C(O)C(F)(F)F
溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

Crude 2-acetylsulfanylmethyl-3-(6-[N,N-bis(tert-butoxycarbonyl)amino]-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester (1.46 g) was dissolved in TFA (5 mL) and stirred for 60 min. Concentration under reduced pressure followed by chromathography (toluene/EtOAc, 1:1→1:10→0:1) gave slightly impure 2-acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester (696 mg, 84%)

WORKUP

后处理

  1. concentrationConcentration under reduced pressure