2-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester → 3-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-2-methyl-propionic acid

HRID 1789824Notes

Reaction equation

HRID 1789824 reaction equation
C([O:3][C:4](=[O:21])[C:5]([CH2:16][S:17]C(=O)C)([CH3:15])[CH2:6][C:7]1[CH:8]=[N:9][C:10]([NH2:14])=[C:11]([CH3:13])[CH:12]=1)C>Cl>[NH2:14][C:10]1[N:9]=[CH:8][C:7]([CH2:6][C:5]([CH2:16][SH:17])([CH3:15])[C:4]([OH:21])=[O:3])=[CH:12][C:11]=1[CH3:13]

Participants

3

Reactant 1

HCID 572012572-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester

Product 1

HCID 101986553-(6-Amino-5-methyl-pyridin-3-yl)-2-mercaptomethyl-2-methyl-propionic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-Acetylsulfanylmethyl-3-(6-amino-5-methyl-pyridin-3-yl)-2-methyl-propionic acid ethyl ester (17 mg, 40 μmol) was dissolved in conc. HCl (2 mL) under argon. The solution was heated to reflux for 150 min. Concentration under reduced pressure gave the title compound as the hydrochloride salt (10.7 mg, 96%).

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux for 150 min
  3. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-b962369971ea4d278e8a5ef08961e63a
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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