Hydrochloric Acid → HCID 9794414, compound

HRID 1789849Notes

Reaction equation

HRID 1789849 reaction equation
Cl.OC(C(F)(F)F)=O.C([O:11][C:12](=[O:27])[CH:13]([CH2:22][S:23]C(=O)C)[CH:14]([CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)[CH3:15])C>>[SH:23][CH2:22][CH:13]([CH:14]([CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)[CH3:15])[C:12]([OH:27])=[O:11]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 131725829HCID 131725829, compound

Product 1

HCID 9794414HCID 9794414, compoundYield 134.6%

Procedure

Conc. hydrochloric acid (4 mL) was added to 2-acetylsulfanylmethyl-3-piperidin4-yl-butyric acid ethyl ester TFA salt (0.101 g, 0.252 mmol) under argon. The reaction was heated to reflux for 5 h and then concentrated under reduced pressure to give a diastereomeric mixture of the title compound (73.7 mg) as the hydrochloride salt.

Workup

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 5 h
  3. concentrationconcentrated under reduced pressure
  4. customto give

Sources & evidence

ORD record
ord-4c6df6aa7f004641b5850608bb4b3299
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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