Hydrochloric Acid → 3-(6-Amino-2-methyl-pyridin-3-yl)-2-mercaptomethyl-propionic acid

Participants

Reaction Steps

Conc. hydrochloric acid (2 mL) was added to 2-acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-2-methyl-pyridin-3-yl)-propionic acid ethyl ester (77 mg, 0.19 mmol) under argon. The reaction was heated to reflux for 110 min and was then concentrated under reduced pressure to give the title compound (39 mg, 76%) as the hydrochloride salt.

Provenance & Evidence