HCID 54201262, compound → HCID 22036122, compound

HRID 1789879Notes

Reaction equation

HRID 1789879 reaction equation
C([O:3][C:4](=[O:28])[CH:5]([CH2:13][C:14]1[CH:15]=[N:16][C:17]([NH:20]C(OC(C)(C)C)=O)=[CH:18][CH:19]=1)[CH:6]([S:9]C(=O)C)[CH2:7][CH3:8])C>Cl>[NH2:20][C:17]1[N:16]=[CH:15][C:14]([CH2:13][CH:5]([CH:6]([SH:9])[CH2:7][CH3:8])[C:4]([OH:28])=[O:3])=[CH:19][CH:18]=1

Participants

3

Reactant 1

HCID 54201262HCID 54201262, compound

Product 1

HCID 22036122HCID 22036122, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 3-acetylsulfanyl-2-(6-tert-butoxycarbonylamino-pyridin-3-ylmethyl)-pentanoic acid ethyl ester/D (19.2 mg; 0.05 mmol) in concentrated HCl (2 mL) was refluxed under argon for 1.5 hours. The reaction mixture was allowed to cool to room temperature and concentrated under reduced pressure to afford 12.9 m, of the title compound as the hydrochloride salt.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customto afford 12.9 m

Sources & evidence

ORD record
ord-77bd6419f2c9443ba5381bda5c4957d3
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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