HCID 53990288, compound → HCID 22036079, compound

HRID 1789896Notes

Reaction equation

HRID 1789896 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][CH:14]([C:20]([O:22]CC)=[O:21])[CH2:15][S:16]C(=O)C)[CH2:9]1)=O)(C)(C)C>Cl>[SH:16][CH2:15][CH:14]([CH2:13][CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1)[C:20]([OH:22])=[O:21]

Participants

3

Reactant 1

HCID 53990288HCID 53990288, compound

Product 1

HCID 22036079HCID 22036079, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 3-(3-acetylsulfanyl-2-ethoxycarbonyl-propyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.52 g; 1.45 mmol) in concentrated HCl (15 mL) was refluxed under argon for 1 h. The reaction mixture was allowed to cool to room temperature and concentrated under reduced pressure to afford a diasteromeric mixture of the title compound as the hydrochloride salt (0.33 g; 100%).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customto afford

Sources & evidence

ORD record
ord-931374e168cd47a79a44f80eab695a77
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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