HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-3-phenyl-propionic acid ethyl ester → 3-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-3-phenyl-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl)-3-phenyl-propionic acid ethyl ester | HCID 53970405 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-(6-Amino-pyridin-3-yl)-2-mercaptomethyl-3-phenyl-propionic acid | HCID 22036147 | — |
Reaction Steps
2-Acetylsulfanylmethyl-3-(6-tert-butoxycarbonylamino-pyridin-3-yl )-3-phenyl-propionic acid ethyl ester (58 mg, 0.125 mmol) was dissolved in conc. HCl (3.0 mL). The solution was heated to reflux for 130 min under argon. Concentration under reduced pressure gave the title compound as the hydrochloride salt (41 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071175B1 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-17582d8f0b60422395c84343561351ad |
| Source note | uspto-grants-2006_07 |