Chloroform → HCID 22036129, compound

HRID 1789925Notes

Reaction equation

HRID 1789925 reaction equation
O[CH:2]([C:6]1[CH:7]=[CH:8][C:9]([NH:12][C:13](=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15])=[N:10][CH:11]=1)[CH2:3][CH2:4][CH3:5].[Cl:19]C(Cl)Cl>S(Cl)(Cl)=O>[ClH:19].[Cl:19][CH:2]([C:6]1[CH:7]=[CH:8][C:9]([NH:12][C:13](=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15])=[N:10][CH:11]=1)[CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 6212ChloroformHCID 22036022HCID 22036022, compound

Product 1

HCID 22036129HCID 22036129, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Conditions

Temperature
55 °C

Procedure

To a solution of N-[5-(1-hydroxy-butyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (1.025 g, 4.09 mmol) in trichloromethane (12 mL), thionylchloride (6 mL) was added and the mixture was heated to 55° C. for 1 h. Then the solution was concentrated under reduced pressure to leave crude N-[5-(1-chloro-butyl)-pyridin-2-yl]-2,2-dimethyl-propionamide hydrochloride as a colourless solid.

Workup

  1. concentrationThen the solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ab020df43bc749e3bbf89b8e358a001a
Source dataset
uspto-grants-2006_07
Patent number
US07071175B1

Reaction notes

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