Potassium Hydroxide → 2,4-Bis[[(3-chloro-2-fluorophenyl)methyl]thio]-7-pteridinamine

HRID 1789944Notes

Reaction equation

HRID 1789944 reaction equation
[NH2:1][C:2]1[C:7]([NH:8][CH2:9][C:10]#[N:11])=[C:6]([S:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=2[F:21])[N:5]=[C:4]([S:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([Cl:30])[C:25]=2[F:31])[N:3]=1.[OH-].[K+]>CO.ClCCl>[Cl:30][C:26]1[C:25]([F:31])=[C:24]([CH2:23][S:22][C:4]2[N:5]=[C:6]([S:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[C:15]=3[F:21])[C:7]3[C:2](=[N:1][C:10]([NH2:11])=[CH:9][N:8]=3)[N:3]=2)[CH:29]=[CH:28][CH:27]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 22037040[[4-Amino-2,6-bis[[(3-chloro-2-fluorophenyl)methyl]thio]-5-pyrimidinyl]amino]acetonitrile

Product 1

HCID 220370352,4-Bis[[(3-chloro-2-fluorophenyl)methyl]thio]-7-pteridinamine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of the product from example 13, step (b) (1.4 g) and potassium hydroxide (110 mg) in methanol (80 ml) and dichloromethane (120 ml) was stirred at room temperature for 24 hours. After evaporation in vacuo, the residue rendered the subtitled compound as a pale yellow solid (1.4 g).

Workup

  1. customAfter evaporation in vacuo

Sources & evidence

ORD record
ord-8b0ef7003d124452b8d43d2ab90b786d
Source dataset
uspto-grants-2006_07
Patent number
US07071193B2

Reaction notes

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