HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 2,4-Bis[[(3-chloro-2-fluorophenyl)methyl]thio]-7-pteridinamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | [[4-Amino-2,6-bis[[(3-chloro-2-fluorophenyl)methyl]thio]-5-pyrimidinyl]amino]acetonitrile | HCID 22037040 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,4-Bis[[(3-chloro-2-fluorophenyl)methyl]thio]-7-pteridinamine | HCID 22037035 | — |
Reaction Steps
A solution of the product from example 13, step (b) (1.4 g) and potassium hydroxide (110 mg) in methanol (80 ml) and dichloromethane (120 ml) was stirred at room temperature for 24 hours. After evaporation in vacuo, the residue rendered the subtitled compound as a pale yellow solid (1.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07071193B2 |
| Source dataset | uspto-grants-2006_07 |
| ORD ID | ord-8b0ef7003d124452b8d43d2ab90b786d |
| Source note | uspto-grants-2006_07 |