Methyl Acrylate → HCID 12469800, compound

HRID 1790037Notes

Reaction equation

HRID 1790037 reaction equation
[NH2:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[C:8]([O:12][CH3:13])(=[O:11])[CH:9]=[CH2:10]>CO>[N:2]1([NH:1][CH2:10][CH2:9][C:8]([O:12][CH3:13])=[O:11])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 166581-Aminopiperidine

Product 1

HCID 12469800HCID 12469800, compoundYield 50.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1-aminopiperidine (100 g, 1.00 mol) in dry MeOH (1.00 L) at 0° C., methyl acrylate (99 mL, 1.10 mol) was added dropwise over 2 h. The resulting mixture was stirred overnight at rt. The solvents were evaporated, hexane was added to the residue, and white solid (impurity) was precipitated. The solid was removed by filtration, and the filtrate was evaporated to give 94.10 g (50.5%) of the desired material as a yellow oil, which was used without purification in Example 13.

Workup

  1. customThe solvents were evaporated
  2. additionhexane was added to the residue, and white solid (impurity)
  3. customwas precipitated
  4. customThe solid was removed by filtration
  5. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-d0cf7eeebaf94d0aba3dad3492e83406
Source dataset
uspto-grants-2006_07
Patent number
US07071207B2

Reaction notes

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