1-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-6-ylamine → HCID 11430678, compound

HRID 1790130Notes

Reaction equation

HRID 1790130 reaction equation
[N:1]1([CH2:6][CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH2:17])[CH:15]=3)[CH:10]=[N:9]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[C:18]1([CH3:34])[CH:23]=[CH:22][C:21]([C:24]2[O:28][C:27]([CH2:29][CH2:30][C:31](O)=[O:32])=[N:26][CH:25]=2)=[CH:20][CH:19]=1>>[CH3:34][C:18]1[CH:19]=[CH:20][C:21]([C:24]2[O:28][C:27]([CH2:29][CH2:30][C:31]([NH:17][C:14]3[CH:15]=[C:16]4[C:11]([CH:10]=[N:9][N:8]4[CH2:7][CH2:6][N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)=[CH:12][CH:13]=3)=[O:32])=[N:26][CH:25]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 112762881-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-6-ylamineHCID 162272953-[5-(4-Methylphenyl)-1,3-oxazol-2-yl]propanoic acid

Product 1

HCID 11430678HCID 11430678, compound

Procedure

According to the procedure for Example 49, 1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-ylamine and 3-(5-p-tolyl-oxazol-2-yl)-propionic acid were processed to provide the title compound. MS (DCI/NH3) MS m/z 444 (M+H)+. 1H NMR (500 MHz, DMSO-d6) δ ppm 1.82 (m, 2 H), 1.98 (m, 2 H), 2.32 (s, 3 H), 2.93 (t, J=7.02 Hz, 2 H), 3.03 (m, 2 H), 3.15 (t, J=7.02 Hz, 2 H), 3.52 (m, 2 H), 3.69 (q, J=5.93 Hz, 2 H), 4.67 (t, J=6.24 Hz, 2 H), 7.10 (m, 1 H), 7.25 (m, 2 H), 7.47 (s, 1 H), 7.55 (m, 2 H), 7.71 (m, 1 H), 8.08 (s, 1 H), 8.31 (s, 1 H), 9.60 (br s, N H).

Sources & evidence

ORD record
ord-f3aeb2ecc15a4adfa6480de630b2755d
Source dataset
uspto-grants-2006_07
Patent number
US07071182B2

Reaction notes

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