HCID 226349, compound → HCID 22036617, compound

HRID 1790132Notes

Reaction equation

HRID 1790132 reaction equation
[N:1]1([CH2:6][CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([NH2:17])[CH:15]=3)[CH:10]=[N:9]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][C:29]([CH:32]=[CH:33][C:34](O)=[O:35])=[CH:28][C:27]=1[O:37][CH3:38])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([O:25][C:26]1[CH:31]=[CH:30][C:29](/[CH:32]=[CH:33]/[C:34]([NH:17][C:14]2[CH:15]=[C:16]3[C:11]([CH:10]=[N:9][N:8]3[CH2:7][CH2:6][N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[CH:12][CH:13]=2)=[O:35])=[CH:28][C:27]=1[O:37][CH3:38])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 226349HCID 226349, compoundHCID 112762881-(2-Pyrrolidin-1-YL-ethyl)-1H-indazol-6-ylamine

Product 1

HCID 22036617HCID 22036617, compound

Procedure

According to the procedure for Example 49, 1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-ylamine and 3-(4-benzyloxy-3-methoxy-phenyl)-acrylic acid were processed to provide the title compound. MS (DCI/NH3) MS m/z 497 (M+H)+; 1H NMR (500 MHz, DMSO-d6) δ ppm 1.85 (m, 2 H), 2.01 (m, 2 H), 3.06 (m, 2 H), 3.55 (m, 2 H), 3.71 (m, 2H), 3.85 (s, 3 H), 4.71 (t, J=6.24 Hz, 2 H), 5.15 (s, 2 H), 6.79 (m, 1 H), 7.12 (m, 1 H), 7.18 (m, 2 H), 7.26 (m, 1 H), 7.35 (m, 1 H), 7.41 (m, 2 H), 7.46 (m, 2 H), 7.55 (m, 1 H), 7.74 (m, 1 H), 8.10 (s, 1 H), 8.41 (s, 1 H), 9.63 (br s, N H).

Sources & evidence

ORD record
ord-d0e86bcd787142f5ac7a47da242a4bc3
Source dataset
uspto-grants-2006_07
Patent number
US07071182B2

Reaction notes

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