HRID1790241

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1049

Pyridine

C5H5N

HCID521874

O-Methylhydroxylamine hydrochloride

CH6ClNO

反应SMILES：CCOC(Cc1ccc(OCCn2c(=O)sc3cc(C(=O)c4ccccc4)ccc32)cc1)C(=O)OC

HCID11584254

未命名化合物

PRODUCTS

产物

反应SMILES：CCOC(Cc1ccc(OCCn2c(=O)sc3cc(C(=NOC)c4ccccc4)ccc32)cc1)C(=O)OC

HCID72808510

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To 30 ml of methanol add the compound obtained in Step C (0.00198 mol), O-methyl-hydroxylamine hydrochloride (0.00594 mol) and pyridine (0.00594 mol). Heat at reflux for 3 hours. Evaporate to dryness. Add 100 ml of hydrochloric acid (1N) and then extract with 50 ml of dichloromethane twice. The organic phase is dried over MgSO4 and then evaporated to yield the title compound.

WORKUP

后处理

temperatureHeat
temperatureat reflux for 3 hours
customEvaporate to dryness
additionAdd 100 ml of hydrochloric acid (1N)
extractionextract with 50 ml of dichloromethane twice
dry with materialThe organic phase is dried over MgSO4
customevaporated

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-e9e46de2e79a488992aeb4f0734723aa
来源数据集: uspto-grants-2006_07
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07071221B2
来源说明: uspto-grants-2006_07

反应SMILES

[C:1]([C:9]1[CH:36]=[CH:35][C:12]2[N:13]([CH2:17][CH2:18][O:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][CH:27]([O:32][CH2:33][CH3:34])[C:28]([O:30][CH3:31])=[O:29])=[CH:22][CH:21]=3)[C:14](=[O:16])[S:15][C:11]=2[CH:10]=1)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:38][O:39][NH2:40].N1C=CC=CC=1>CO>[CH2:33]([O:32][CH:27]([CH2:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][CH2:18][CH2:17][N:13]2[C:12]3[CH:35]=[CH:36][C:9]([C:1](=[N:40][O:39][CH3:38])[C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[CH:10][C:11]=3[S:15][C:14]2=[O:16])=[CH:21][CH:22]=1)[C:28]([O:30][CH3:31])=[O:29])[CH3:34]