Methanol → HCID 86760131, compound

HRID 1790260Notes

Reaction equation

HRID 1790260 reaction equation
[CH3:1][O:2][N:3]=[C:4]([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[C:5]1[CH:34]=[CH:33][C:8]2[N:9]([CH2:13][CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH:23]4[C:27]5[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=5[O:25][C:24]4=[O:32])=[CH:18][CH:17]=3)[C:10](=[O:12])[S:11][C:7]=2[CH:6]=1.[CH3:41][OH:42]>S(=O)(=O)(O)O>[OH:42][C:41]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[CH:23]([CH2:22][C:19]1[CH:18]=[CH:17][C:16]([O:15][CH2:14][CH2:13][N:9]2[C:8]3[CH:33]=[CH:34][C:5]([C:4](=[N:3][O:2][CH3:1])[C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)=[CH:6][C:7]=3[S:11][C:10]2=[O:12])=[CH:21][CH:20]=1)[C:24]([O:25][CH3:26])=[O:32]

Participants

4

Reactant 2

HCID 887MethanolHCID 86760130HCID 86760130, compound

Product 1

HCID 86760131HCID 86760131, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

1.5 g of the compound obtained in Step B, in 50 ml of methanol and 0.1 ml of concentrated sulphuric acid, are heated at reflux for 2 hours. The solvent is then evaporated off, the residue is hydrolysed and the precipitate obtained is chromatographed on silica gel (eluant: AcOEt/toluene 5/95).

Workup

  1. temperatureat reflux for 2 hours
  2. customThe solvent is then evaporated off
  3. customthe precipitate obtained
  4. customis chromatographed on silica gel (eluant: AcOEt/toluene 5/95)

Sources & evidence

ORD record
ord-c1cef0531c944d71b832c83ba61f51c7
Source dataset
uspto-grants-2006_07
Patent number
US07071221B2

Reaction notes

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